I used a Pi3 as a guinea pig and tried installing OpenZFS on it using a pair of Seagate Expansion 2TB drives connected via the USB ports. Initially I tried with Raspbian because that is what the SD card in the Pi had installed. During the install it complained it was a 32 bit operating system and it wasn't going to work.
I went to image the SD card with Raspberry Pi OS 64 bit (Lite) and Win32 Disk Imager was having trouble (speeds of 0.45MB/sec) writing to the SD card. I replaced it with a new one. After booting up I added the buster-backports repo to the /etc/apt/sources.list and got the operating system up to date. Start by changing the password via raspi-config.
sudo raspi-config
deb http://deb.debian.org/debian buster-backports main contrib non-free
sudo apt update
sudo apt upgrade -y
sudo rm /etc/apt/sources.list.d/vscode.list
sudo rm /etc/apt/trusted.gpg.d/microsoft.gpg
sudo reboot
After it restarted I then told it to install OpenZFS from buster-backports which picked up OpenZFS 2.0.2.
sudo apt install -t buster-backports zfs-dkms raspberrypi-kernel-headers -y
It pops up a warning about licenses not being compatible which you have to acknowledge before it proceeds. It takes a while to build. Once its done reboot again and you should now have OpenZFS installed on a Raspberry Pi. I created a mirror with two external HDD (devices sda and sdb)
sudo zpool create pool1 mirror /dev/sda /dev/sdb -f
I then copied some files off my NFS server. It was quite slow which I attribute to using a Pi3 (slow USB ports, slow processor and limited memory). To make sure it all worked, reboot and it should automatically mount the drives in the pool when it starts up. You can check by doing a scrub:
sudo zpool scrub pool1
zpool status
Where to next?
At this point its booting off the SD card and the pool is using both disks. What would be nice is to have a bootable ZFS pool rather than using the SD card as a boot device.
If you were after more speed you could use SSD's instead of hard disks but you pay more for the capacity. Something like the Samsung T2 would be ideal. Just remember to do a zpool trim command regularly.
I expect its possible to use a USB hub to get more ports so you can have more drives but think the performance wouldn't be as good as directly plugged devices.
The ZFS forums recommend 1GB of memory for each TB of storage so you would get better performance with a 4GB or 8GB Pi4.
Update 5 Apr 2021
Added the kernel-headers to the install command and clarified what to add to /etc/apt/sources.list.
I used a Pi4 8GB and two external USB3 HDD this time and it was somewhat quicker at copying files. Buster-backports has OpenZFS 2.0.3 as of writing.